RibetrilTM A, the patented active compound in MitoActiveTM, is a unique bioactive polyphenolalkaloid found only in specific varieties of red- and blackcurrants. RibetrilTM A displays potent triple enzyme inhibition of IkappaB kinase ß (IKK-ß), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5). The triple enzyme inhibitory activity of MitoActiveTM makes sense on a whole new level. Inhibition of PDE4 and PDE5 is linked to activation of PGC-1α, a principal regulator of mitochondrial biogenesis and function. PDE5 inhibition is also known for its ability to induce vascular smooth muscle relaxation. Inhibition of IKK-ß is linked to improved tissue regeneration. IKK-ß is part of the inflammation cascade and related to risk of decreased tissue regeneration capacity.
- BerryShield Liquid
- Elderberry Liquid Extract 16:1
- Bulk liquid
- Ready to drink
Mitochondrial boosting by RibetrilTM A
The RibetrilTM A in MitoActiveTM stimulates mitochondrial amount and improves the mitochondrial ability to respond with increased energy output in muscle cells during stress. These parameters are paramount in athletic performance.
Repeated Cooper Test
In a Cooper test on 5 trained athletes supplemented
with MitoActiveTM daily for 3 weeks, a significant
increase in performance after 2 and 3 weeks of 4.2%
and 4.5% compared to baseline was observed.
Figure 1 Performance in repeated Cooper tests (relative change). *p < 0.05, **p < 0.001
Studie fra Københavns Universitet
Daily treatment with MitoActiveTM or placebo in 31 highly trained athletes exposed to intensified training for 3 weeks supplementation resulted in prevention of an increase in lactic acid urinary excretion and prevention of a fall in pyruvic acid.
Urinary excretion seen in the placebo group at day 21 compared to day 1, indicating a decrease of anaerobic metabolism and better maintenance of aerobic metabolism in the treatment group.
MitoActiveTM for skin is positioned as MitoBeautyTM
Berries are generally perceived as the essence of vitality and not without reason; the properties of MitoBeautyTM
are truly revitalizing for the skin. MitoBeautyTM was originally researched for its skin healing properties with
impressive results. It is clinically documented to significantly increase the microcirculation and moisture of the
skin and decrease wrinkles by acting from the inside. MitoBeautyTM is marketed as a skin vitality boosting product
with anti-wrinkle properties, available both as liquid and powder. Biotin has been added to the liquid formulation
enabling relevant EU authorized health claims (biotin contributes to maintenance of normal skin, hair and mucous membranes). Biotin can be added to the powder (optional).
In a 12 week French clinical study with 50 healthy women and men of 40-65 years of age, supplemented orally with 30 ml of MitoActiveTM with Biotin daily, objective measurements demonstrated:
- Significant anti-wrinkle and smoothing effect already after 6 weeks
- Sustained anti-wrinkle and smoothing effect after12 weeks
- Significantly increased microcirculation in the skinand a significant moisturizing effect
The increased microcirculation strongly supports the finding of an anti-wrinkle effect since regeneration of the skin is dependent on a good blood circulation.